Effects Timelines for MtoF and FtoM
IDENTITY EXPRESSION GROUP :: HRT :: HRT
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Effects Timelines for MtoF and FtoM
Remember: Everyone is different so the adage YMMV (Your Millage May Vary) holds true here as well.
MtoF Effects and Expected Time Course of Feminizing Hormonesa
Effect Expected onsetb effect b Expected maximum effect b
Body fat redistribution 3–6 months 2–5 years
Decreased muscle mass/strength 3–6 months 1–2 yearsc
Softening of skin/decreased oiliness 3–6 months Unknown
Decreased libido 1–3 months 1–2 years
Decreased spontaneous erections 1–3 months 3–6 months
Male sexual dysfunction Variable Variable
Breast growth 3–6 months 2–3 years
Decreased testicular volume 3–6 months 2–3 years
Decreased sperm production Variable Variable
Thinning and slowed growth of body
and facial hair
6–12 months > 3 yearsd
Male pattern baldness
No regrowth, loss stops 1–3 months 1–2 years
a Adapted with permission from Hembree et al. (2009). Copyright 2009, The Endocrine Society.
b Estimates represent published and unpublished clinical observations.
c Significantly dependent on amount of exercise.
d Complete removal of male facial and body hair requires electrolysis, laser treatment, or both.
FtoM Effects and Expected Time Course of Masculinizing Hormonesa
Effect Expected onsetb Expected maximum effectb
Skin oiliness/acne 1–6 months 1–2 years
Facial/body hair growth 3–6 months 3–5 years
Scalp hair loss >12 monthsc Variable
Increased muscle mass/strength 6–12 months 2–5 yearsd
Body fat redistribution 3–6 months 2–5 years
Cessation of menses 2–6 months n/a
Clitoral enlargement 3–6 months 1–2 years
Vaginal atrophy 3–6 months 1–2 years
Deepened voice 3–12 months 1–2 years
a Adapted with permission from Hembree et al. (2009). Copyright
2009, The Endocrine Society.
b Estimates represent published and unpublished clinical observations.
c Highly dependent on age and inheritance; may be minimal.
MtoF Effects and Expected Time Course of Feminizing Hormonesa
Effect Expected onsetb effect b Expected maximum effect b
Body fat redistribution 3–6 months 2–5 years
Decreased muscle mass/strength 3–6 months 1–2 yearsc
Softening of skin/decreased oiliness 3–6 months Unknown
Decreased libido 1–3 months 1–2 years
Decreased spontaneous erections 1–3 months 3–6 months
Male sexual dysfunction Variable Variable
Breast growth 3–6 months 2–3 years
Decreased testicular volume 3–6 months 2–3 years
Decreased sperm production Variable Variable
Thinning and slowed growth of body
and facial hair
6–12 months > 3 yearsd
Male pattern baldness
No regrowth, loss stops 1–3 months 1–2 years
a Adapted with permission from Hembree et al. (2009). Copyright 2009, The Endocrine Society.
b Estimates represent published and unpublished clinical observations.
c Significantly dependent on amount of exercise.
d Complete removal of male facial and body hair requires electrolysis, laser treatment, or both.
FtoM Effects and Expected Time Course of Masculinizing Hormonesa
Effect Expected onsetb Expected maximum effectb
Skin oiliness/acne 1–6 months 1–2 years
Facial/body hair growth 3–6 months 3–5 years
Scalp hair loss >12 monthsc Variable
Increased muscle mass/strength 6–12 months 2–5 yearsd
Body fat redistribution 3–6 months 2–5 years
Cessation of menses 2–6 months n/a
Clitoral enlargement 3–6 months 1–2 years
Vaginal atrophy 3–6 months 1–2 years
Deepened voice 3–12 months 1–2 years
a Adapted with permission from Hembree et al. (2009). Copyright
2009, The Endocrine Society.
b Estimates represent published and unpublished clinical observations.
c Highly dependent on age and inheritance; may be minimal.
IDENTITY EXPRESSION GROUP :: HRT :: HRT
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